Chemistry: Medicinal Chemistry, Organic Chemistry, Biological Chemistry
CHEMISTRY, BIOCHEMISTRY, PHARMACOLOGY, PROTEIN SURFACE MIMETICS, GPCR REGULATION, ENZYME REGULATION, ANTI-INFLAMMATORY RESEARCH, ANTI-INFECTIVES RESEARCH, ANTI-CANCER RESEARCH, NEURODEGENERATIVE RESEARCH, CARDIOVASCULAR RESEARCH
Chemistry researchers in our group develop expertise in medicinal chemistry, organic chemistry and biological chemistry; conducting solution and solid phase organic synthesis; structure determination through 2D NMR spectroscopy; computer-aided molecular and drug design; and study interactions between small molecules, and with proteins, DNA and RNA. We particularly focus on developing general approaches to basic and strategic chemistry that are applicable to diverse classes of chemical structures. We spend a great deal of time controlling molecular shape, intramolecular hydrogen bonding, nucleophilicity/electrophilicity in order to influence chemical reactivity and molecular recognition. Outcomes are new chemical reactions, novel chemical mechanisms, novel organic compounds, new chemical structures; new enzyme inhibitors, protein agonists and antagonists, and small molecule structural mimics of protein surfaces; and new leads to drugs, diagnostics and vaccines. Our group includes biochemists, immunologists and pharmacologists, who collaborate in studies on those of our compounds that have been designed to have biological activities.
Selected Publications (Medicinal, Organic, Biological Chemistry)
2022:
Modifying a hydroxyl patch in glucagon-like peptide 1 produces biased agonists with unique signaling profiles. Wang P, Hill TA, Mitchell J, Fitzsimmons RL, Xu W, Loh Z, Suen JY, Lim J, Iyer A, Fairlie DP. J Med Chem 2022, 65, 11759-11775.
Tuning electrostatic and hydrophobic surfaces of aromatic rings to enhance membrane association and cell uptake of peptides. de Araujo AD, Hoang HN, Lim J, Mak JYW, Fairlie DP. Angew Chem Int Ed Engl 2022, 61, e202203995.
Landscaping macrocyclic peptides: stapling hDM2-binding peptides for helicity, protein affinity, proteolytic stability and cell uptake. de Araujo AD, Lim J, Wu KC, Hoang HN, Nguyen HT, Fairlie DP. RSC Chem Biol 2022, 3, 895-904.
Helical structure in cyclic peptides: effect of N-methyl amides versus esters. Wu C, Hoang HN, Hill TA, Lim J, Kok WM, Akondi K, Liu L, Fairlie DP. Chem Commun 2022, 58, 12475-12478.
Quantitative affinity measurement of small molecule ligand binding to major histocompatibility complex class-I-related protein 1 MR1. Wang CJH, Awad W, Liu L, Mak JYW, Veerapen N, Illing PT, Purcell AW, Eckle SBG, McCluskey J, Besra GS, Fairlie DP, Rossjohn J, Le Nours J. J Biol Chem 2022, 298, 102714.
QSAR classification models for prediction of hydroxamate histone deacetylase inhibitor activity against malaria parasites. Hesping E, Chua MJ, Pflieger M, Qian Y, Dong L, Bachu P, Liu L, Kurz T, Fisher GM, Skinner-Adams TS, Reid RC, Fairlie DP, Andrews KT, Gorse AJP. ACS Infect Dis 2022, 8, 106-117.
2021:
Chemical modulators of mucosal associated invariant T cells. Mak JYW, Liu L, Fairlie DP. Accounts of Chemical Research 2021, 54, 3462-3475.
Connecting hydrophobic surfaces in cyclic peptides increases membrane permeability.Hoang HN, Hill TA, Fairlie DP. Angew Chem Int Ed Engl 2021, 60, 8385-8390.
Fortified coiled coils: enhancing mechanical stability with lactam or metal staples.López-García P, de Araujo AD, Bergues-Pupo AE, Tunn I, Fairlie DP*, Blank KG*. Angew Chem Int Edit 2021, 60, 232-236.
HDAC7 inhibition by phenacetyl and phenylbenzoyl hydroxamates.Mak JYW, Wu KC, Gupta PK, Barbero S, McLaughlin MG, Lucke AJ, Tng J, Lim J, Loh Z, Sweet MJ, Reid RC, Liu L, Fairlie DP. J Med Chem 2021, 64, 2186-2204.
De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex. Kai-En Chen, Qian Guo, Timothy A Hill, Yi Cui, Amy K Kendall, Zhe Yang, Ryan J Hall, Michael D Healy, Joanna Sacharz, Suzanne J Norwood, Sachini Fonseka, Boyang Xie, Robert C Reid, Natalya Leneva, Robert G Parton, Rajesh Ghai, David A Stroud, David P Fair Science Advances 2021, 7(49), eabg4007.
Histone deacetylase inhibitor AR-42 and achiral analogues kill malaria parasites in vitro and in mice.Chua MJ, Tng J, Hesping E, Fisher GM, Goodman CD, Skinner-Adams T, Do D, Lucke AJ, Reid RC, Fairlie DP, Andrews KT. Int J Parasiol Drugs Drug Resist 2021, 17, 118-127.
Late-stage hydrocarbon conjugation and cyclization in synthetic peptides and proteins. de Araujo AD, Nguyen HT, Fairlie DP. ChemBioChem 2021, 22, 1784-1789.
Taking the Myc out of cancer: Toward therapeutic strategies to directly inhibit c-Myc.S Madden, AD de Araujo, M Gerhardt, DP Fairlie, JM Mason. Molecular Cancer 2021, 20, 3.
Targeting class IIa HDACs: insights from phenotypes and inhibitors. Liu L, Dong L, Bourguet E, Fairlie DP. Curr Med Chem 2021, 28, 8628-8672.
Synthesis of benzoxazole-based vorinostat analogs and their antiproliferative activity. Mantzourani C, Gkikas D, Kokotos A, Nummela P, Theodoropoulou MA, Wu KC, Fairlie DP, Politis PK, Ristimäki A, Kokotos G. Bioorg Chem 2021, 114, 105132.
A nucleotide analog prevents colitis associated cancer via Β-catenin independently of inflammation and autophagy.Sheng YH, Giri R, Davies J, Schreiber V, Alabbas S, Movva R, He Y, Wu A, Hooper J, McWhinney B, Oancea I, Kijanka G, Hasnain S, Lucke AJ, Fairlie DP, McGuckin MA, Florin TH, Begun J. Cell Mol Gastroenterol Hepatol 2021,11, 33-53.
2020:
The molecular basis underpinning the potency and specificity of MAIT cell antigens. Awad W, Ler G, Xu W, Keller AN, Mak JYW, Yi X, Lim J, Liu L, Eckle SBG, Le Nours J, McCluskey J, Corbett AJ, Fairlie DP, Rossjohn J. Nat Immunol 2020, 21, 400-411.
Achiral derivatives of hydroxamate AR-42 potently inhibit class I HDAC enzymes and cancer cell proliferation. Tng J, Lim J, Wu KC, Lucke AJ, Xu W, Reid RC, Fairlie DP. J Med Chem 2020, 63, 5956-5971.
Potent thiophene antagonists of human complement C3a receptor with anti-Inflammatory activity. Rowley JA, Reid RC, Poon EKY, Wu KC, Lim J, Lohman RJ, Hamidon JK, Yau MK, Halili MA, Durek T, Iyer A, Fairlie DP. J Med Chem 2020, 63, 529-541.
Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens.McWilliam HEG, Mak JYW, Awad W, Zorkau M, Cruz-Gomez S, Lim HL, Yan Y, Wormald S, Dagley LF, Eckle SBG, Corbett AJ, Liu H, Li S, Reddiex SJJ, Mintern JD, Liu L, McCluskey J, Rossjohn J, Fairlie DP*, Villadangos JA*. Proc Natl Acad Sci USA 2020, 117, 24974-24985.
Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition.Kennedy AJ, Sundström L, Geschwindner S, Poon EKY, Jiang Y, Chen R, Cooke R, Johnstone S, Madin A, Lim J, Liu Q, Lohman RJ, Nordqvist A, Fridén-Saxin M, Yang W, Brown DG, Fairlie DP, Dekker N. Commun Biol 2020, 3(1), 782.
Systemic delivery of peptides by the oral route: Formulation and medicinal chemistry approaches. Brayden DJ, Hill TA, Fairlie DP, Maher S, Mrsny RJ. Adv Drug Deliv Rev. 2020, 157, 2-36.
High cell permeability does not predict oral bioavailability for analogues of cyclic heptapeptide sanguinamide A. Nielsen DS, Lohman RJ, Hoang HN, Fairlie DP, Hill TA. Aust J Chem 2020, 73, 344-451.
2019:
Crystal structures of protein-bound cyclic peptides. Malde AK, Hill TA, Iyer A, Fairlie DP. Chem Rev 2019, 119, 9861-9914.
A novel long-range n to π* interaction secures the smallest known α-helix in water. Hoang HN, Wu C, Hill TA, de Araujo AD, Bernhardt PV, Liu L, Fairlie DP. Angew Chem Int Ed Engl 2019, 58, 18873-18877.
Twists or Turns: stabilising alpha vs beta turns in tetrapeptides. Hoang HN, Hill TA, Ruiz-Gómez G, Diness F, Mason JM, Wu C, Abbenante G, Shepherd NE, Fairlie DP. Chemical Science 2019, 10, 10595-10600.
Mirror image pairs of cyclic hexapeptides have different oral bioavailabilities and metabolic stabilities. Lohman RJ, Nielsen DS, Kok WM, Hoang HN, Hill TA, Fairlie DP. Chem Commun 2019, 55, 13362-13365.
Computer modelling and synthesis of deoxy and monohydroxy analogues of a ribitylaminouracil bacterial metabolite that potently activates human T cells. Ler GJM, Xu W, Mak JYW, Liu L, Bernhardt PV. Fairlie DP. Chemistry 2019, 25, 15594-15608.
Oxazole-benzenesulfonamide derivatives inhibit HIV-1 reverse transcriptase interaction with cellular eEF1A and reduce viral replication. Rawle DJ, Li D, Wu Z, Wang L, Choong M, Lor M, Reid RC, Fairlie DP, Harris J, Tachedjian G, Poulsen SA, Harrich D. J Virol 2019, 93(12), pii: e00239-19.
Structure-activity relationships of wollamide cyclic hexapeptides with activity against drug-resistant and intracellular mycobacterium tuberculosis. Khalil ZG, Hill TA, De Leon Rodriguez LM, Lohman RJ, Hoang HN, Reiling N, Hillemann D, Brimble MA, Fairlie DP, Blumenthal A, Capon RJ. Antimicrob Agents Chemother 2019, 63(3), pii: e01773-18.
2018:
Chemical Approaches To Modulating Complement-Mediated Diseases. Iyer A, Xu W, Reid RC, Fairlie DP. J Med Chem 2018, 61, 3253-3276.
Bicyclic Helical Peptides as Dual Inhibitors Selective for Bcl2A1 and Mcl-1 Proteins. de Araujo AD, Lim J, Wu KC, Xiang Y, Good AC, Skerlj R, Fairlie DP. J Med Chem 2018, 61, 2962-2972.
Glucuronic acid as a helix-inducing linker in short peptides. Wu C, Hoang HN, Liu L, Fairlie DP. Chemical Communications 2018, 54, 2162-2165.
Chemically diverse helix-constrained peptides using selenocysteine crosslinking. Dantas de Araujo A, Perry SR, Fairlie DP. Org Lett 2018, 20, 1453-1456.
Contiguous hydrophobic and charged surface patches in short helix-constrained peptides drive cell permeability. Perry SR, Hill TA, de Araujo AD, Hoang HN, Fairlie DP. Org Biomol Chem 2018, 16, 367-371.
2017:
Stabilising short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells. Mak JYW, Xu W, Reid RC, Corbett AJ, Meehan B, Wang H, Chen Z, Rossjohn J, McCluskey J, Liu L*, Fairlie* DP. Nature Commun 2017, 8, 14599.
Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a. Lohman R-J, Hamidon JK, Reid RC, Rowley JA, Yau M-K, Halili MA, Nielsen DS, Lim J, Wu K-C, Loh Z, Do A, Suen JY, Iyer A, Fairlie DP. Nature Commun 2017, 8, 351.
Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells. Keller AN, Eckle SBG, Xu W, Liu L, Hughes VA, Mak JYW, Meehan B, Pediongco T, Birkinshaw RW, Chen Z, Wang H, D’Souza C, Kjer-Nielsen L, Gheradin NA, Godfrey DI, Kostenko L, Corbett AJ, Purcell AW, Fairlie DP*, McCluskey J*, Rossjohn J*. Nature Immunol 2017, 18, 402-411.
Total synthesis of the Mycobacterium tuberculosis dideoxymycobactin-838 and stereoisomers: Diverse CD1a-restricted T cells display a common hierarchy of lipopeptide recognition. Cheng JMH, Liu L, Pellicci DG, Reddiex S, Cotton RN, Cheng T-Y, Young DC, Van Rhijn I, Moody DB, Rossjohn J, Fairlie DP, Godfrey DI, Williams SJ. Chem Eur J 2017, 23, 1694 – 1701.
Stereoelectronic effects on dienophile separation influence the Diels-Alder synthesis of molecular cleftsStoermer MJ, Wickramasinghe WA, Byriel KA, Hockless DCR, Skelton BW, Sobolev AN, White AH, Mak JYW, Fairlie DP. Eur J Org Chem 2017, 6793–6796.
Biased signaling by agonists of protease activated receptor 2. Jiang Y, Yau M-K, Kok WM, Lim J, Wu K-C, Liu L, Hill TA, Suen JY, Fairlie DP. ACS Chem Biol 2017, 12, 1217-1226.
Orally Absorbed Cyclic Peptides. Nielsen DS, Shepherd NE, Xu W, Lucke AJ, Stoermer MJ, Fairlie DP. Chem Rev 2017, 117, 8094–8128.
Electrophilic helical peptides that bind covalently, irreversibly and selectively in a protein-protein interaction site. Dantas de Araujo A, Lim J, Good AC, Skerlj RT, Fairlie DP*. ACS Med Chem Lett 2017, 8, 22−26.
Downsizing Proto-oncogene cFos to Short Helix-Constrained Peptides That Bind Jun. Baxter D, Perry SR, Hill TA, Kok WM, Zaccai NR, Brady RL, Fairlie DP, Mason JM. ACS Chem Biol 2017, 12, 2051-2061.
Helix-constraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta arrestin 2 signalling. Plisson F, Hill TA, Mitchell JM, Hoang HN, de Araujo AD, Xu W, Cotterell A, Edmonds DJ, Stanton RV, Derksen DR, Loria PM, Griffith DA, Price DA, Liras S, Fairlie DP*. Eur J Med Chem 2017, 127, 703-714.
Europium-Labeled Synthetic C3a Protein as a Novel Fluorescent Probe for Human Complement C3a Receptor. de Araujo AD, Wu C, Wu K-C, Reid RC, Durek T, Lim J, Fairlie DP. Bioconjugate Chem 2017, 28, 1669-1676.
Quinazolinone derivatives as inhibitors of homologous recombinase RAD51. Ward A, Dong L, Harris JM, Khanna KK, Al-Ejeha F, Fairlie DP, Wiegmans AP, Liu L. Bioorg Med Chem Lett 2017, 27, 3096-3100.
Tolyporphin Macrocycles from the Cyanobacterium Tolypothrix nodosa Selectively Bind Copper and Silver and Reverse Multidrug Resistance. Prinsep MR, Appleton TG, Hanson GR, Lane I, Smith CD, Puddick J, Fairlie DP. Inorg Chem 2017, 56, 5577-5585.
Alpha helix nucleation by a simple cyclic tetrapeptide. Hoang HN, Wu C, Beyer RL, Hill TA, Fairlie DP. Aust J Chem 2017, 70, 213–219.
2016:
Helix nucleation by the smallest known alpha helix in water. Hoang HN, Driver RW, Beyer RL, Hill TA, de Araujo AD, Plisson F, Harrison RS, Goedecke L, Shepherd NE, Fairlie DP*. Angew Chem Int Edit 2016, 55, 8275-8279.
PAR2 modulators derived from GB88. Yau MK, Liu L, Suen JY, Lim J, Lohman RJ, Cotterell AJ, Barry GD, Mak JYC, Vesey DA, Reid RC, Fairlie DP*. ACS Med Chem Lett 2016, 7, 1179-1184.
Potent Small Agonists Of Protease Activated Receptor 2. Yau MK, Suen JY, Xu W, Lim J, Liu L, Adams MN, He Y, Hooper JD, Reid RC, Fairlie DP*. ACS Med Chem Lett 2016, 7, 105–110.
Downsizing the BAD BH3 peptide to small constrained αlpha helices with improved ligand efficiency. Shepherd NE, Harrison RS, Ruiz-Gomez G, Abbenante G, Mason JM, Fairlie DP*. Org Biomol Chem 2016, 14, 10939-10945. [special issue on cyclic peptides]
Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists. Seow V, Lim J, Cotterell AJ, Yau MK, Xu W, Lohman RJ, Kok WM, Stoermer MJ, Sweet MJ, Reid RC, Suen JY, Fairlie DP*. Science Reports 2016, 6, 24575. doi: 10.1038/srep24575.
Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity. Yau MK, Liu L, Lim J, Lohman RJ, Cotterell AJ, Suen JY, Vesey DA, Reid RC, Fairlie DP*. Bioorg Med Chem Lett 2016, 26, 986-991.
Histone Deacetylase Inhibitors Promote Mitochondrial Reactive Oxygen Species Production and Bacterial Clearance by Human Macrophages. Ariffin JK, das Gupta K, Kapetanovic R, Iyer A, Reid RC, Fairlie DP, Sweet MJ. Antimicrob Agents Chemother 2016, 60, 1521-1529.
Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015). Yau MK, Lim J, Liu L, Fairlie DP*. Expert Opinion on Therapeutic Patents 2016, 26, 471-483.
Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2. Lieu T, Savage E, Zhao P, Edgington-Mitchell L, Barlow N, Bron R, Poole DP, McLean P, Lohman RJ, Fairlie DP, Bunnett NW. Br J Pharmacol. 2016, 173, 2752-2765.
Differential anti-inflammatory activity of low versus high dose HDAC inhibitors in human macrophages and collagen induced arthritis in rats. Lohman RJ, Iyer A, Fairlie TJ, Cotterell A, Gupta P, Reid RC, Vesey DA, Sweet MJ, Fairlie DP*. J Pharmacol Exp Ther 2016, 356, 387-396.
Truncated glucagon-like peptide-1 and exendin-4 α-conotoxin pl14a peptide chimeras maintain potency, α-helicity and reveal interactions vital for cAMP signaling in vitro. Swedberg JE, Schroeder CI, Mitchell J, Fairlie DP, Edmonds DJ, Griffith DA, Ruggeri RB, Derksen DR, Loria PM, Price DA, Liras S, Craik DJ. J Biol Chem 2016, 291, 15778-15787.
Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions. Philippe G, Huang YH, Cheneval O, Lawrence N, Zhang Z, Fairlie DP, Craik DJ, de Araujo AD, Henriques ST. Biopolymers 2016, 106, 853-863.
Stapling peptides using cysteine crosslinking. Fairlie DP, de Araujo AD. Biopolymers 2016, 106, 843-852.
2015:
Short hydrophobic peptides with cyclic constraints are potent glucagon-like peptide-1 receptor (GLP-1R) agonists. Hoang HN, Song K, Hill TA, Derksen DR, Edmonds DJ, Kok WM, Limberakis C, Liras S, Loria PM, Mascitti V, Mathiowetz AM, Mitchell JM, Piotrowski DW, Price DA, Stanton RV, Suen JY, Withka JM, Griffith DA, Fairlie DP*. J Med Chem 2015, 58, 4080-4085.
Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system. Halili MA, Bachu P, Lindahl F, Bechara C, Mohanty B, Reid RC, Scanlon MJ, Robinson CV, Fairlie DP*, Martin JL*. ACS Chem Biol 2015, 10, 957-964.
Peptide inhibitors of the Escherichia coli DsbA oxidative machinery essential for bacterial virulence. Duprez W, Premkumar L, Halili M, Lindahl F, Reid RC, Fairlie DP*, Martin JL*. J Med Chem 2015, 58, 577-587.
Potent complement C3a receptor agonists derived from oxazole amino acids: Structure-activity relationships. Singh R, Reed AN, Chu P, Scully CC, Yau MK, Suen JY, Durek T, Reid RC, Fairlie DP*. Bioorg Med Chem Lett 2015, 25, 5604-5608.
Helix-constrained nociceptin peptides are potent agonists and antagonists of ORL-1 and nociception. Lohman RJ, Harrison RS, Ruiz-Gomez G, Hoang HN, Shepherd NE, Chow S, Hill TA, Madala PK, Fairlie DP*. Vitamins and Hormones 2015, 97, 1-55.
Flexibility versus Rigidity for Orally Bioavailable Cyclic Hexapeptides. Nielsen DS, Lohman RJ, Hoang HN, Hill TA, Jones A, Lucke AJ, Fairlie DP*. Chembiochem 2015, 16, 2289-2293.
Recognition of Vitamin B precursors and byproducts by Mucosal Associated Invariant T cells. Eckle SB, Corbett AJ, Keller A, Chen Z, Godfrey DI, Liu L, Mak JY, Fairlie DP*, Rossjohn J*, McCluskey J*. J Biol Chem 2015, 290, 30204-30211.
Toward peptide-based inhibitors as therapies for Parkinson's disease. Mason JM, Fairlie DP. Future Med Chem 2015, 7, 2103-2105.
Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists. Swedberg JE, Schroeder CI, Mitchell JM, Durek T, Fairlie DP, Edmonds DJ, Griffith DA, Ruggeri RB, Derksen DR, Loria PM, Liras S, Price DA, Craik DJ. Eur J Med Chem 2015, 103, 175-184.
Comparing Sixteen Scoring Functions for Predicting Biological Activities of Ligands for Protein Targets. Xu W, Lucke AJ, Fairlie DP*. J Mol Graphics Modelling 2015, 57, 76-88.
Three Homology Models of PAR2 Derived from Different Templates: Applications to Antagonist Discovery. Perry SR, Xu W, Wirija A, Lim J, Yau MK, Stoermer MJ, Lucke AJ, Fairlie DP*. J Chem Inf Model 2015, 55, 1181-1191.
Repurposing Registered Drugs as Antagonists for Protease-Activated Receptor 2. Xu W, Lim J, Goh CY, Suen JY, Jiang Y, Yau MK, Wu KC, Liu L, Fairlie DP*. J Chem Inf Model 2015, 55, 2079-2084.
Virtual Screening of Peptide and Peptidomimetic Fragments Targeted to Inhibit Bacterial Dithiol Oxidase DsbA. Duprez W, Bachu P, Stoermer MJ, Tay S, McMahon RM, Fairlie DP*, Martin JL*. PLoS One 2015, 10(7): e0133805.
Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites. Engel JA, Jones AJ, Avery VM, Sumanadasa SD, Ng SS, Fairlie DP, Adams TS, Andrews KT. Int J Parasitol Drugs Drug Resist 2015, 5, 117-126.
2014:
Stereoelectronic effects dictate molecular conformation and biological function of heterocyclic amides. Reid RC, Yau MK, Singh R, Lim J, Fairlie DP*. J Am Chem Soc 2014, 136, 11914-11917. Recommended by Faculty1000Prime.
Potent Heterocyclic Ligands for Human Complement C3a Receptor Reid RC, Yau M-K, Singh R, Hamidon JK, Lim J, Stoermer MJ, Fairlie DP*. J Med Chem 2014, 57, 8459-8470.
Improving on Nature: Making a Cyclic Heptapeptide Orally Bioavailable. Nielsen DS, Hoang HN, Lohman RJ, Hill TA, Lucke AJ, Craik DJ, Edmonds DJ, Griffith DA, Rotter CJ, Ruggeri RB, Price DA, Liras S, Fairlie DP*. Angew Chem Int Edit 2014, 53, 12059-12063.
Constraining Cyclic Peptides To Mimic Protein Structure Motifs. Hill TA, Shepherd NE, Diness F, Fairlie DP*. Angew Chem Int Edit 2014, 53, 13020-13041.
Comparative Alpha Helicity of Cyclic Pentapeptides in Water. de Araujo AD, Hoang HN, Kok WM, Diness F, Gupta G, Hill TA, Driver RW, Price DA, Liras S, Fairlie DP*. Angew Chem Int Edit 2014, 53, 6965-6999.
T cell activation by transitory neo-antigens derived from distinct microbial pathways. Corbett AJ, Eckle SBG, Birkinshaw RW, Liu L, Patel O, Mahony J, Chen Z, Reantra-goon R, Meehan B, Cao H, Williamson NA, Strugnell RA, Sinderen DV, Mak JYW, Fairlie DP*, Lars Kjer-Nielsen*, Rossjohn J*, McCluskey J*. Nature, 2014, 509(7500), 361-365. ISI Highly Cited.
Helical cyclic pentapeptides constrain HIV-1 Rev peptide for enhanced RNA binding. Harrison RS, Shepherd NE, Hoang HN, Beyer RL, Ruiz-Gómez G, Kelso MJ, WM Kok, TA Hill, Abbenante G, Fairlie DP*. Tetrahedron 2014, 70, 7645-7650 [special issue on cyclic peptides].
Cyclic Penta- and Hexa- Leucine Peptides Without N-Methylation Are Orally AbsorbedHill TA, Lohman RJ, Hoang HN, Nielsen DS, Scully CCG, Kok WM, Liu L, Lucke AJ, Stoermer MJ, Schroeder CI, Chaousis S, Colless B, Bernhardt PV, Edmonds DJ, Griffith DA, Rotter CJ, Ruggeri RB, Price DA, Liras S, Craik DJ, Fairlie DP*. ACS Med Chem Lett 2014, 5, 1148-1151. Faculty1000Prime Recommendation.
Lysine acetylation in sexual stage malaria parasites is a target for antimalarial small molecules. Trenholme K, Marek L, Duffy S, Pradel G, Fisher G, Hansen FK, Skinner-Adams TS, Butterworth A, Julius Ngwa C, Moecking J, Goodman CD, McFadden GI, Sumanadasa SD, Fairlie DP, Avery VM, Kurz T, Andrews KT. Antimicrob Agents Chemother 2014, 58, 3666-3678.
Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients. Wang CK, Northfield SE, Colless B, Chaousis S, Hamernig I, Lohman RJ, Nielsen DS, Schroeder CI, Liras S, Price DA, Fairlie DP*, Craik DJ*. Proc Natl Acad Sci U S A. 2014, 111, 17504-17509.
Crystal Structure of the Dithiol Oxidase DsbA Enzyme from Proteus Mirabilis Bound Non-Covalently to an Active Site Peptide Ligand. Kurth F, Duprez W, Premkumar L, Schembri M, Fairlie DP*, Martin JL*. J Biol Chem 2014, 289, 19810-19822.
2013:
Downsizing a Human Inflammatory Protein to a Small Molecule with Equal Potency and Functionality. Reid RC, Yau M-K, Singh R, Hamidon JK, Reed AN, Chu P, Suen JY, Stoermer MJ, Blakeney JS, Lim J, Faber JM, Fairlie DP. Nature Communications 2013, 4, 2802. doi: 10.1038/ncomms3802.
Towards Drugs for Protease-Activated Receptor 2 (PAR2). Yau MK, Liu L, Fairlie DP. J Med Chem 2013, 56, 7477–7497.
Efficient chemical synthesis of human complement protein C3a. Ghassemian A, Wang CI, Yau MK, Reid RC, Lewis RJ, Fairlie DP, Alewood PF, Durek T. Chem Commun 2013, 49, 2356-2358.
Recognition of vitamin B metabolites by mucosal-associated invariant T cells. Patel O, Kjer-Nielsen L, Nours JL, Eckle SBG, Bikinshaw R, Beddoe T, Corbett AJ, Liu L, Miles JJ, Mehan B, Reantragoon R, Sandoval-Romero ML, Sullivan LC, Brooks AG, Chen Z, Fairlie DP, McCluskey J, Rossjohn J. Nature Communications 2013, 4, 2142 doi: 10.1038/ncomms3142.
The Future of Peptide-based Drugs. Craik DJ, Fairlie DP, Liras S, Price D. Chem Biol Drug Des, 2013, 81, 136-147. ISI Highly Cited. ISI Hot Paper. [>100 citations]
Truncated and helix-constrained peptides with high affinity and specificity for the cFos coiled-coil of AP-1. Rao T, Ruiz-Gómez G, Hill TA, Hoang HN, Fairlie DP, Mason JM. PLoS One 2013, 8(3), e59415.
2012:
Catalyst-Free N-arylation Using Unactivated Fluorobenzenes. Diness F, Fairlie DP. Angew. Chem. Int. Edit. 2012, 51, 8012-8016.
MR1 presents microbial vitamin B metabolites to MAIT cells. Kjer-Nielsen L, Patel O, Nours JL, Meehan B, Corbett AJ, Liu L, Bhati M, Chen Z, Kostenko L, Reantragoon R, Williamson NA, Purcell AW, Dudek NL, McConville MJ, O’Hair RAJ, Khairallah GN, Godfrey DI, Fairlie DP, Rossjohn J, McCluskey J. Nature 2012, 491, 717-723. ISI Highly Cited. ISI Hot Paper.[>100 citations]
Total Synthesis, Structure, and Oral Absorption of a Thiazole Cyclic Peptide, Sanguinamide A. Nielsen DS, Hoang HN, Lohman RJ, Diness F, Fairlie DP. Org Lett. 2012, 14, 5720–5723.
Folding pentapeptides into left and right handed alpha helices. Hoang, HN, Abbenante G, Hill TA, Ruiz-Gomez G, Fairlie DP. Tetrahedron, 2012, 68, 4513–4516 [special issue on foldamers].
2011:
Protein Alpha Turns Recreated in Structurally Stable Small Molecules. Hoang HN, Driver RW, Beyer RL, Malde AK, Le GT, Abbenante G, Mark AE, Fairlie DP. Angew. Chem. Int. Ed. Engl. 2011, 50, 11107-11111.
VIP: Amyloid Formation from an α-Helix Peptide Bundle Is Seeded by 310-Helix Aggregates. Singh Y, Sharpe PC, Hoang HN, Lucke AJ, McDowall AW, Bottomley SP, Fairlie DP. Chem. Eur. J. 2011, 17, 151-160.
Synthesis of the Thiazole-Thiazoline Fragment of Largazole Analogues. Diness F, Nielsen DS, Fairlie DP. J. Org. Chem. 2011, 76, 9845-9851.
Ex Vivo Activity of Histone Deacetylase Inhibitors against Multidrug-Resistant Clinical Isolates of Plasmodium falciparum and P. vivax. Marfurt J, Chalfein F, Prayoga P, Wabiser F, Kenangalem E, Piera KA, Fairlie DP, Tjitra E, Anstey NM, Andrews KT, Price RN. Antimicrob. Agents Chemother. 2011, 55, 961-966.
2010:
Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency. Harrison RS, Shepherd NE, Hoang HN, Ruiz-Gómez G, Hill TA, Driver RW, Desai VS, Young PR, Abbenante G, Fairlie DP. Proc Natl Acad Sci U S A. 2010, 107, 11686-11691.
Novel agonists and antagonists for human protease activated receptor 2. Barry GD, Suen JY, Le GT, Cotterell A, Reid RC, Fairlie DP. J. Med. Chem. 2010, 53, 7428-7440.
Novel Helix-Constrained Nociceptin Derivatives Are Potent Agonists and Antagonists of ERK Phosphorylation and Thermal Analgesia in Mice. Harrison RS, Ruiz-Gómez G, Hill TA, Chow SY, Shepherd NE, Lohman RJ, Abbenante G, Hoang HN, Fairlie DP. J. Med. Chem. 2010, 53, 8400–8408.
Non-covalent tripeptidylbenzyl and cyclohexyl amine inhibitors of the cysteine protease caspase-1. Löser R, Abbenante G, Madala PK, Halili M, Le GT, Fairlie DP. J. Med. Chem. 2010, 53, 2651-2655.
Selective hexapeptide agonists and antagonists for human complement C3a receptor. Scully CC, Blakeney JS, Singh R, Hoang HN, Abbenante G, Reid RC, Fairlie DP. J. Med. Chem. 2010, 53, 4938-4948.
Update 1 of: Over One Hundred Peptide-Activated G Protein-Coupled Receptors Recognize Ligands with Turn Structure. Gloria Ruiz-Gmez, Joel D. A. Tyndall, Bernhard Pfeiffer, Giovanni Abbenante and David P. Fairlie. Chemical Reviews, 2010, 110(4), PR1-PR41.
Update 1 of: Proteases Universally Recognize Beta Strands in their active sites. Madala PK, Tyndall JD, Nall T, Fairlie DP. Chemical Reviews 2010, 110(6), PR1-PR31.
Update 1 of: Beta-Strand Mimetics. Loughlin WA, Tyndall JD, Glenn MP, Hill TA, Fairlie DP. Chemical Reviews 2010, 110(6), PR32-PR69.
Inhibitors Selective For HDAC6 In Enzymes and Cells. Gupta PK, Reid RC, Liu L, Lucke AJ, Broomfield SA, Andrews MR, Sweet MJ, Fairlie DP. Bioorg. Med. Chem. Lett. 2010, 20, 7067-7070.
Antimalarial Histone Deacetylase Inhibitors Containing Cinnamate or NSAID Components. Wheatley NC, Andrews KT, Tran TL, Lucke AJ, Reid RC, Fairlie DP. Bioorg. Med. Chem. Lett. 2010, 20, 7080-7084.
2009:
Left- and Right-Handed Alpha-Helical Turns in Homo- and Hetero-Chiral Helical Scaffolds. Shepherd NE, Hoang HN, Abbenante G, Fairlie DP. J Am Chem Soc. 2009, 131, 15877-15886.
Ma MT, Hoang HN, Scully CCG, Appleton TG, Fairlie DP Metal Clips That Induce Unstructured Pentapeptides To Be Alpha Helical In Water J Am Chem Soc 2009, 131, 4505-4512.
Structure activity relationships for substrate based inhibitors of human complement factor B. Ruiz-Gómez, G.; Lim, J.; Halili, MA; Le, GT; Madala, PK; Abbenante G.; Fairlie DP J Med Chem 2009, 52, 6042-6052.
Complement Factor C2, Inhibiting A Latent Serine Protease In The Classical Pathway Of Complement Activation. Halili MA, Ruiz-Gómez G, Le GT, Abbenante G, Fairlie DP. Biochemistry 2009, 48, 8466–8472.
A cyclic beta-strand tripeptide with an alpha-helix like CD spectrum. Driver R. W.; Hoang, H. N.; Abbebante, G, Fairlie, D. P. Org. Lett. 2009, 11, 3092–3095.
