Researchers
Background:
I started my Research Project in Professor David Fairlie’s Lab as a part of my Master degree from The University Of Queensland. My research project focused on the investigation of G-Protein Coupled Receptors (GPCRs) signal pathways associated with cancer, immune and inflammatory diseases. I then took on a Research Assistant position in Professor Fairlie’s Lab.
Research interest
Imaging & microscopy
Human disease
Immune responses
Inflammatory mechanism
Publication:
de Araujo, Aline D., Lim, Junxian, Wu, Kai-Chen, Xiang, Yibin, Good, Andrew C., Skerlj, Renato and Fairlie, David P. (2018)Bicyclic helical peptides as dual inhibitors selective for Bcl2A1 and Mcl-1 proteins. Journal of Medicinal Chemistry, 61 7: 2962-2972.
Jiang, Yuhong, Yau, Mei-Kwan, Lim, Junxian, Wu, Kai-Chen, Xu, Weijun, Suen, Jacky Y and Fairlie, David P (2017)A potent antagonist of protease-activated receptor 2 that inhibits multiple signaling functions in human cancer cells. The Journal of pharmacology and experimental therapeutics, 364 2: 246-257.
Lohman, Rink-Jan, Hamidon, Johan K., Reid, Robert C., Rowley, Jessica A., Yau, Mei-Kwan, Halili, Maria A., Nielsen, Daniel S., Lim, Junxian, Wu, Kai-Chen, Loh, Zhixuan, Do, Anh, Suen, Jacky Y., Iyer, Abishek and Fairlie, David P. (2017) Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a. Nature Communications, 8(1): 351.
Dantas de Araujo, Aline, Wu, Chongyang, Wu, Kai-Chen, Reid, Robert C., Durek, Thomas, Lim, Junxian and Fairlie, David P. (2017)Europium-labeled synthetic C3a protein as a novel fluorescent probe for human complement C3a receptor. Bioconjugate Chemistry, 28 6: 1669-1676.
Jiang, Yuhong, Yau, Mei-Kwan, Kok, W. Mei, Lim, Junxian, Wu, Kai-Chen, Liu, Ligong, Hill, Timothy A., Suen, Jacky Y. and Fairlie, David P. (2017)Biased signaling by agonists of protease activated receptor 2. ACS Chemical Biology, 12 5: 1217-1226.
Xu, Weijun, Lim, Junxian, Goh, Chai-Yeen, Suen, Jacky Y., Jiang, Yuhong, Yau, Mei-Kwan, Wu, Kai-Chen, Liu, Ligong and Fairlie, David P. (2015)Repurposing Registered Drugs as Antagonists for Protease-Activated Receptor 2. Journal of Chemical Information and Modeling, 55 10: 2079-2084.
Chiu, L.-H., Chen, S.-C., Wu, K.-C., Yang, C.-B., Fang, C.-L., Lai, W.-F. T. and Tsai, Y.-H. (2011), Differential effect of ECM molecules on re-expression of cartilaginous markers in near quiescent human chondrocytes. J. Cell. Physiol., 226: 1981–1988.
