Kai-Chen (Kathy) Wu


First name: Kai-Chen (Kathy)

Surname: Wu

Web Site:



I started my Research Project in Professor David Fairlie’s Lab as a part of my Master degree from The University Of Queensland. My research project focused on the investigation of G-Protein Coupled Receptors (GPCRs) signal pathways associated with cancer, immune and inflammatory diseases. I then took on a Research Assistant position in Professor Fairlie’s Lab.


Research interest


Imaging & microscopy

Human disease

Immune responses

Inflammatory mechanism



de Araujo, Aline D.Lim, JunxianWu, Kai-ChenXiang, YibinGood, Andrew C.Skerlj, Renato and Fairlie, David P. (2018)Bicyclic helical peptides as dual inhibitors selective for Bcl2A1 and Mcl-1 proteins. Journal of Medicinal Chemistry61 7: 2962-2972.


Jiang, YuhongYau, Mei-KwanLim, JunxianWu, Kai-ChenXu, WeijunSuen, Jacky Y and Fairlie, David P (2017)A potent antagonist of protease-activated receptor 2 that inhibits multiple signaling functions in human cancer cells. The Journal of pharmacology and experimental therapeutics364 2: 246-257.


Lohman, Rink-JanHamidon, Johan K.Reid, Robert C.Rowley, Jessica A.Yau, Mei-KwanHalili, Maria A.Nielsen, Daniel S., Lim, Junxian, Wu, Kai-ChenLoh, ZhixuanDo, AnhSuen, Jacky Y.Iyer, Abishek and Fairlie, David P. (2017) Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a. Nature Communications, 8(1): 351.


Dantas de Araujo, AlineWu, ChongyangWu, Kai-ChenReid, Robert C.Durek, ThomasLim, Junxian and Fairlie, David P. (2017)Europium-labeled synthetic C3a protein as a novel fluorescent probe for human complement C3a receptor. Bioconjugate Chemistry28 6: 1669-1676.


Jiang, YuhongYau, Mei-KwanKok, W. MeiLim, JunxianWu, Kai-ChenLiu, LigongHill, Timothy A.Suen, Jacky Y. and Fairlie, David P. (2017)Biased signaling by agonists of protease activated receptor 2. ACS Chemical Biology12 5: 1217-1226.


Xu, WeijunLim, Junxian, Goh, Chai-Yeen, Suen, Jacky Y.Jiang, YuhongYau, Mei-KwanWu, Kai-ChenLiu, Ligong and Fairlie, David P. (2015)Repurposing Registered Drugs as Antagonists for Protease-Activated Receptor 2. Journal of Chemical Information and Modeling55 10: 2079-2084.

Chiu, L.-H., Chen, S.-C., Wu, K.-C., Yang, C.-B., Fang, C.-L., Lai, W.-F. T. and Tsai, Y.-H. (2011), Differential effect of ECM molecules on re-expression of cartilaginous markers in near quiescent human chondrocytes. J. Cell. Physiol., 226: 1981–1988.

Former Group Members