Researchers
Background:
I graduated as Master of pharmaceutical sciences from University of Copenhagen, Faculty for Pharmaceutical Sciences in 2011. My undergraduate studies included a bachelor project concerning various formulations of miconazole nitrate, a 1-year scholarship founded full-time research project related to epigenetics, and an overseas internship as synthetic organic chemist in David P. Fairlie’s group.
Following my graduation I returned to the Fairlie Group. I received the international student Ph.D. scholar ship from University of Queensland to commence my research in the area of “Orally Biovailable Cyclic Peptides”.
Key achievements from my Ph.D. project to date:
- Novel application of NMR spectroscopy to improve oral bioavailability of cyclic peptides
- Authored and co-authored five peer reviewed scientific publications on orally bioavailable cyclic peptides
- Oral presentation at the American Chemical Society meeting
- Multiple award winning posters at Australian and international conferences
- Development of in vivo pharmacokinetic assay for cyclic peptides
Interests:
Industry orientated drug discovery and research, cyclic peptides, oral bioavailability, peptide chemistry, organic synthesis, solid phase chemistry, bioorganic chemistry, applied NMR spectroscopy, medicinal chemistry and drug discovery beyond “rule of five”, and project management.
Specialized areas:
Orally bioavailable peptides, synthetic organic chemistry, NMR-spectroscopy, solid phase chemistry, peptide synthesis, cyclic peptides, metabolic stability, ADME, pharmacokinetics, analytical methods (NMR, MS, LCMS, MS-MS, HPLC).
Future directions:
Join pharmaceutical industry with no preference to geographical location; apply and expand my knowledge on bioavailable cyclic peptides; acquire project management skills from a stimulating work environment.
Prizes and awards:
- American Peptide Society Student Award 2015
- University of Queensland Graduate School International Travel Award 2014
- School of Chemistry & Molecular Biosciences Tutor Excellence Award 2014
- Best poster - American Peptide Symposium in Orlando, Florida, 6/2015
- Best poster - Early Career Researchers Symposium, Australia – 11/2014
- Best poster - Brisbane Biological & Organic Chemistry Symposium, Australia – 12/2013
- Runner up - Early Career Researchers Symposium 2012, Australia – 11/2012
- Best poster - Division of Chemistry and Structural Biology Symposium, Australia – 12/2012
Publication list:
1. Nielsen, D. S.; Hoang, H. N.; Lohman, R.; Hill, T. A. et. al. Angew. Chem. Int. Ed. 2014, 53, 12059-63. “Improving on Nature: Making a Cyclic Heptapeptide Orally Bioavailable”
2. Hill, T. A.; Lohman, R., Houng, H. N., Nielsen, D. S. et. al. ACS Med. Chem. Lett. 2014, 5, 1148-51. “Cyclic Penta- and Hexaleucine Peptides without N-Methylation Are Orally Absorbed”
3. Wang, C. K.; Northfield, S. E.; Colless, B.; Chaousis, S.; Hamernig, I.; Lohman, R.; Nielsen, D. S. et. al. PNAS 2014, 111, 17504-09. “Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients”
4. Nielsen, D. S.; Hoang, H. N.; Lohman, R; Diness, F; Fairlie, D. P. Org. Lett. 2012, 14, 5720-23. “Total synthesis, structure, and oral absorption of a thiazole cyclic peptide, sanguinamide A”
5. Diness, F; Nielsen, D. S.; Fairlie, D. P. J. Org. Chem. 2011, 76, 9845-51. “Synthesis of the thiazole-thiazoline fragment of largazole analogues”
