Researchers
Background:
My Honours and PhD projects (at SMMS, UQ) involved synthesis, purification, characterization & NMR-based determination of three-dimensional structures of novel metallopeptides. After award of my PhD, I moved to IMB and took my post-doctorate fellowship with Professor Fairlie. Since then, I have been working with world-class experts in chemistry and biology, and “playing” with state of the art equipments/instruments such as 900, 750, 600, 500, 400 MHz NMR; Circular Dichroism (CD), Fluorescence spectrometers (FP assay), Computer Modelling and 3D structure calculations from multi-dimensional NMR data.
My research interests:
* Mechanisms of folding/unfolding of peptides/proteins and in studying factors that influence folding, such as solvent interactions, hydrogen bonds, non-covalent interactions between side chains, charge interactions, and interactions with metal ions
* Application NMR (1D and 2D), CD techniques, FP assay and Computer modelling toward structure elucidation of peptides, peptidomimetics, ligand-receptor interactions and metallopeptides.
My Honours and PhD projects (at SMMS, UQ) involved synthesis, purification, characterization & NMR-based determination of three-dimensional structures of novel metallopeptides. After award of my PhD, I moved to IMB and took my post-doctorate fellowship with Professor Fairlie. Since then, I have been working with world-class experts in chemistry and biology, and “playing” with state of the art equipments/instruments such as 900, 750, 600, 500, 400 MHz NMR; Circular Dichroism (CD), Fluorescence spectrometers (FP assay), Computer Modelling and 3D structure calculations from multi-dimensional NMR data.
My research interests:
* Mechanisms of folding/unfolding of peptides/proteins and in studying factors that influence folding, such as solvent interactions, hydrogen bonds, non-covalent interactions between side chains, charge interactions, and interactions with metal ions
* Application NMR (1D and 2D), CD techniques, FP assay and Computer modelling toward structure elucidation of peptides, peptidomimetics, ligand-receptor interactions and metallopeptides.
Publications:
“A Cyclic beta-Strand Tripeptide with an alpha-Helix Like CD Spectrum”
Driver, RW; Hoang, HN; Abbenante, G; Fairlie, D. P. Organic Letters 2009; 11; 3092-3095.
“Metal Clips That Induce Unstructured Pentapeptides To Be alpha-Helical In Water.” Ma, M. T.; Hoang, H. N.; Scully, C. C. G.; Appleton, T. G.; Fairlie, D. P. J. Am. Chem. Soc. 2009; 131; 4505-4512.
“Linkage Isomerism in the Binding of Pentapeptide Ac-His(Ala)(3)His-NH2 to (Ethylenediamine)Palladium(II): Effect of the Binding Mode on Peptide Conformation.” Hoang, H.N.; Bryant G. K.; Kelso, M. J.; Appleton, T. G.; Fairlie, D. P. Inorg. Chem. 2008; 47; 9439-9449.
“Modular α-Helical Mimetics With Antiviral Activity Against Respiratory Syncitial Virus.” Shepherd, N. E.; Hoang, H. N.; Desai, V. S.; Letouze, E.; Young, P. R.; Fairlie D. P.
J. Am. Chem. Soc. 2006; 128; 13284-13289.
“Organic Azide Inhibitors Of Cysteine Proteases.” G. T. Le, G. Abbenante, P. Madala, H. N. Hoang, D. P. Fairlie. J. Am. Chem. Soc. 2006; 128; 12396-12397.
“Self-Condensation of a Thiazole-Peptide Bearing a 21-Membered Loop into a Library of Gaint Macrocycles with Multiple Othogonal Loops.” Singh, Y., Hoang, H. N.; Flanagan, B.; Fairlie, D. P. Org. Lett. 2006, 8(6), 1053-1056.
“New Insights Into Growth Hormone Action.” Waters, M. J.; Hoang, H. N.; Fairlie, D. P.; Pelekanos, R. A.; Brown, R. J. Journal of Endocrinology. 2006, 36, 1-7.
“Single Turn Peptide Alpha Helices with Exceptional Stability in Water.” Shepherd, Nicholas E.; Hoang, Huy N.; Abbenante, Giovanni.; Fairlie, David P. . J. Am. Chem. Soc. 2005; 127(9), 2974-2983.
“Metal-Induced Folding Of A Short Unstructured Peptide Into An Alpha Helix Via Turn Conformations In Water. Kinetic Versus Thermodynamic Products.” Renée L. Beyer, Huy N. Hoang, Trevor G. Appleton, David P. Fairlie. J. Am. Chem. Soc. 2004; 126(46), 15096-15105.
“Alpha-Turn Mimetics: Short Peptide Alpha-Helices Composed of Cyclic Metallopentapeptide Modules.” Kelso, M. J.; Beyer, R. L.; Hoang, H.N.; Lakdawala, A. S.; Snyder, J. P.; Oliver, W. V.; Robertson, T. A.; Appleton, T. G.; Fairlie, D. P. J. Am. Chem. Soc. 2004; 126(15), 4828-4842.
“A Cyclic metallopeptide induce alpha helicity in short peptide fragments of thermolysin.” Kelso, M. J.; Hoang, H.N.; Oliver, W. V.; Sokolenko, N.; March, D. R.; Appleton, T. G.; Fairlie, D. P. Angewandte Chemie, international Edition (2003), 42(4), 421-424.
“The First Solution Structure of a Single alpha Helical Turn. A Pentapeptide Alpha helix Stabilized by a Metal Clip.” Kelso, M. J.; Hoang, H.N.; Appleton, T. G.; Fairlie, D. P. J. Am. Chem. Soc. 2000; 122(42), 10488-10489.
“A Cyclic beta-Strand Tripeptide with an alpha-Helix Like CD Spectrum”
Driver, RW; Hoang, HN; Abbenante, G; Fairlie, D. P. Organic Letters 2009; 11; 3092-3095.
“Metal Clips That Induce Unstructured Pentapeptides To Be alpha-Helical In Water.” Ma, M. T.; Hoang, H. N.; Scully, C. C. G.; Appleton, T. G.; Fairlie, D. P. J. Am. Chem. Soc. 2009; 131; 4505-4512.
“Linkage Isomerism in the Binding of Pentapeptide Ac-His(Ala)(3)His-NH2 to (Ethylenediamine)Palladium(II): Effect of the Binding Mode on Peptide Conformation.” Hoang, H.N.; Bryant G. K.; Kelso, M. J.; Appleton, T. G.; Fairlie, D. P. Inorg. Chem. 2008; 47; 9439-9449.
“Modular α-Helical Mimetics With Antiviral Activity Against Respiratory Syncitial Virus.” Shepherd, N. E.; Hoang, H. N.; Desai, V. S.; Letouze, E.; Young, P. R.; Fairlie D. P.
J. Am. Chem. Soc. 2006; 128; 13284-13289.
“Organic Azide Inhibitors Of Cysteine Proteases.” G. T. Le, G. Abbenante, P. Madala, H. N. Hoang, D. P. Fairlie. J. Am. Chem. Soc. 2006; 128; 12396-12397.
“Self-Condensation of a Thiazole-Peptide Bearing a 21-Membered Loop into a Library of Gaint Macrocycles with Multiple Othogonal Loops.” Singh, Y., Hoang, H. N.; Flanagan, B.; Fairlie, D. P. Org. Lett. 2006, 8(6), 1053-1056.
“New Insights Into Growth Hormone Action.” Waters, M. J.; Hoang, H. N.; Fairlie, D. P.; Pelekanos, R. A.; Brown, R. J. Journal of Endocrinology. 2006, 36, 1-7.
“Single Turn Peptide Alpha Helices with Exceptional Stability in Water.” Shepherd, Nicholas E.; Hoang, Huy N.; Abbenante, Giovanni.; Fairlie, David P. . J. Am. Chem. Soc. 2005; 127(9), 2974-2983.
“Metal-Induced Folding Of A Short Unstructured Peptide Into An Alpha Helix Via Turn Conformations In Water. Kinetic Versus Thermodynamic Products.” Renée L. Beyer, Huy N. Hoang, Trevor G. Appleton, David P. Fairlie. J. Am. Chem. Soc. 2004; 126(46), 15096-15105.
“Alpha-Turn Mimetics: Short Peptide Alpha-Helices Composed of Cyclic Metallopentapeptide Modules.” Kelso, M. J.; Beyer, R. L.; Hoang, H.N.; Lakdawala, A. S.; Snyder, J. P.; Oliver, W. V.; Robertson, T. A.; Appleton, T. G.; Fairlie, D. P. J. Am. Chem. Soc. 2004; 126(15), 4828-4842.
“A Cyclic metallopeptide induce alpha helicity in short peptide fragments of thermolysin.” Kelso, M. J.; Hoang, H.N.; Oliver, W. V.; Sokolenko, N.; March, D. R.; Appleton, T. G.; Fairlie, D. P. Angewandte Chemie, international Edition (2003), 42(4), 421-424.
“The First Solution Structure of a Single alpha Helical Turn. A Pentapeptide Alpha helix Stabilized by a Metal Clip.” Kelso, M. J.; Hoang, H.N.; Appleton, T. G.; Fairlie, D. P. J. Am. Chem. Soc. 2000; 122(42), 10488-10489.
