Publications 2012-2019

2019

Yan J, Allen S, McDonald E, Das I, Mak JYW, Liu L, Fairlie DP, Meehan BS, Chen Z, Corbett A, Varelias A, Smyth M, Teng MWL. MAIT cells promote tumor intiation, growth, and metastasis via tumor MR1. 

Cancer Discovery 2019, 10, 124-141. 

 

Hoang HN, Wu C, Hill TA, de Araujo AD, Berhnhardt PV, Liu L, Fairlie DP. A long-range n to pi* interaction secures the smallest known α-helix in water. 

Angew Chem Int Edit 2019, 58, 18873-18877.

 

Le Nours J, Gherardin NA, Ramarathinam SH, Awad W, Wiede F, Gully BS, Khandokar Y, Praveena T, Wubben JM, Sandow JJ, Webb Andrew I, von Borstel A, Rice MT, Redmond SJ, Seneviratna R, Sandoval-Romero ML, Li S, Souter MN, Eckle SBG, Corbett AJ, Reid HH, Liu L, Fairlie DP, Giles EM, Westall GP, Tothill RW, Davey M, Berry R, Tiganis T, McCluskey J, Pellicci DG, Purcell AW, Uldrich AP, Godfrey DI, = Rossjohn J. A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1, 

Science 2019, 366, 1522-1527.

 

Malde AK,  Hill TA, Iyer A, Fairlie DP. 

Crystal Structures of Protein-Bound Cyclic Peptides. 

Chemical Reviews 2019, 119, 9861-9914.

 

Hoang HN, Hill TA, Ruiz-Gómez G, Diness F, Mason JM, Abbenante G,  Shepherd NE, Fairlie DP. Twists or Turns: stabilizing alpha versus beta turns in tetrapeptides. 

Chem Sci 2019, 10, 10595-10600. 

 

Ler GJM, Xu W, Mak JYW, Bernhardt PV, Liu L, Fairlie DP. Computer modelling and synthesis of deoxy and monohydroxy analogues of a ribitylaminouracil bacterial metabolite that potently activates human T cells. 

Chem Eur J 2019, 25(68):15594-15608. 

 

Wang H, Kjer-Nielsen L, Shi M, D’Souza C, Pediongco TJ, Cao H, Kostenko L, Lim X, Eckle SBG, Meehan BS, Zhu T, Wang Z, Zhao Z, Mak JYW, Fairlie DP, Teng MWL, Rossjohn J, Yu D, Fazekas de St Groth B, Lovrecz G, Lu L, McCluskey J, Strugnell RA, Corbett AJ, Chen Z. IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection. 

Science Immunol 2019, 4(41), eaaw0402. 

 

Koay H-F, Su S, Zalcenstein D, Daley SR, Comerford I, Miosge L, Gregor C, Konstantinov IE, d’Udekem Y, Baldwin T, Hickey P, Berzins SP, Mak JYW, Sontani Y, Roots CM, Sidwell T, Kallies A, Chen Z, Nüssing S, Kedzierska K, Mackay LK, McColl SR, Deenick E, Fairlie DP, McCluskey J, Goodnow CC, Ritchie ME, Belz GT, Naik SH, Pellicci DG, Godfrey DI. A divergent transcriptional landscape underpins the development and functional branching of MAIT cells. 

Science Immunology 2019, 4(41), eaay6039.

 

Koay HF, Gherardin NA, Xu C, Seneviratna R, Zhao Z, Chen Z, Fairlie DP, McCluskey J, Pellicci DG, Uldrich AP, Godfrey DI. Diverse MR1-restricted T cells in mice and humans. 

Nature Commun 2019, 10, 2243.  

 

Lohman RJ, Nielsen DS, Kok WM, Hoang HN, Hill T, Fairlie DP. Mirror image pairs of cyclic hexapeptides have different oral bioavailabilities and metabolic stabilities. 

Chem Commun 2019, 55, 13362-13365.

 

Juno JA, Wragg K, Amarasena T, Meehan B, Mak JYW, Liu L, Fairlie DP, McCluskey J, Eckle S, Kent SJ. MAIT cells upregulate α4β7 in response to acute Simian Immunodeficiency Virus/Simian HIV infection but are resistant to peripheral depletion in pigtail macaques. 

J Immunol 2019, 202, 2105-2120.

 

Rawle DJ, Li D, Wu Z, Wang L, Choong M, Lor M, Reid RC, Fairlie DP, Harris J, Tachedjian G, Poulsen SA, Harrich D. Oxazole-benzenesulfonamide derivatives inhibit HIV-1 reverse transcriptase interaction with cellular eEF1A and reduce viral replication.

J Virology 2019, 93(12). pii: e00239-19.

 

Loh Z, Fitzsimmons RL, Reid RC, Ramnath D, Clouston A, Irvine KM, Powel EE, Schroder K, Stow JL, Sweet MJ, Fairlie DP, Iyer A. HDAC inhibitors suppress hepatic inflammation and fibrosis by attenuating IL-33 dependent natural ILC2 activation. 

Br J Pharmacol 2019, 176, 3775-3790.

 

Meade RM, Fairlie DP, Mason JM. Alpha-synuclein structure and Parkinson's disease - lessons and emerging principles. 

Mol Neurodegener 2019, 14(1), 29.

 

Han Y, Tian L, Ma F, Tesch G, Vesey DA, Gobe GC, Lohman RJ, Morais C, Suen JY, Fairlie DP, Nikolic-Paterson DJ. Pharmacological inhibition of protease-activated receptor-2 reduces crescent formation in rat nephrotoxic serum nephritis.

Clin Exp Pharmacol Physiol 2019, 46, 456-464. 

 

Ma FY, Han Y, Ozols E, Chew P, Vesey DA, Gobe GC, Morais C, Lohman RJ, Suen JY, Johnson DW, Fairlie DP, Nikolic-Paterson DJ. Protease-activated receptor 2 does not contribute to renal inflammation or fibrosis in the obstructed kidney. 

Nephrology (Carlton) 2019, 24, 983-991.

 

Chen Z, Wang H, D’Souza C, Koay H-F, Meehan BS, Zhao Z, Pediongco T, Shi M, Zhu T, Wang B, Kjer-Nielsen L, Eckle SBG, Rossjohn J, Fairlie DP, Godfrey DI, Strugnell RA, McCluskey J, Corbett AJ. Characterization and Purification of Mouse MucosalAssociated Invariant T (MAIT) Cells. 

Curr Protocol Immunol 2019, 127(1), e89. 

 

Souter MNT, Loh L, Li S, Meehan BS, Gherardin NA, Godfrey DI, Rossjohn J, Fairlie DP, Pellicci DG, Chen Z, Kjer-Nielsen L, Corbett AJ, McCluskey J, Eckle SBG, Characterization of Human Mucosalassociated Invariant T (MAIT) Cells. 

Curr Protocol Immunol 2019, 127(1), e90.

 

Khalil ZG, Hill TA, De Leon Rodriguez LM, Lohman RJ, Hoang HN, Reiling N, Hillemann D, Brimble MA, Fairlie D, Blumenthal A, Capon RJ. Structure-activity relationships of wollamide cyclic hexapeptides with activity against drug-resistant and intracellular Mycobacterium tuberculosis. 

Antimicrob Agents Chemother 2019, 63(3), pii: e01773-18. 

 

 

2018

Iyer A, Xu W, Reid RC, Fairlie DP. Chemical approaches to modulating complement-mediated disease. 

J Med Chem 2018, 61, 3253-3276. 

 

de Araujo AD, Lim J, Wu K-C, Xiang Y, Good AC,  Skerlj R, Fairlie DP. Bicyclic helical peptides as dual inhibitors selective for Bcl2A1 and Mcl-1 proteins. 

J Med Chem 2018, 61, 2962-2972. 

 

de Araujo AD, Perry S, Fairlie DP. Chemically diverse helix-constrained peptides using selenocysteine crosslinking.

Org Lett 2018, 20, 1453-1456. 

 

Wang H, D’Souza C, Lim X, Kostenko L, Pediongco T, Eckle SB, Meehan B, Shi M, Wang N, Liu L, Mak JY, Fairlie DP, Iwakura Y, Gunnersen JM, Stent AW, Godfrey DI, Rossjohn J, Westall GP, Kjer-Nielsen L, Strugnell RA, McCluskey J, Corbett AJ, Hinks TSC, Chen Z. MAIT cells protect against pulmonary Legionella longbeachae infection.

Nature Commun 2018, 9, 3350. 

 

Varelias A, Bunting MD, Ormerod KL, Koyama M, Olver SD, Straube J, Kuns RD, Robb RJ, Henden AS, Cooper L, Lachner N, Gartlan KH, Lantz O, Kjer-Nielsen L, Mak JYW, Fairlie DP, Clouston AD, McCluskey J, Rossjohn J, Lane SW, Hugenholtz P, Hill GR. Recipient mucosal-associated invariant T Cells control GVHD within the colon.

J Clin Invest 2018, 128, 1919-1936. 

 

Nguyen H, Bastian D, Vaena SG, Zhang M, Kuril S, Dany M, Dai M, Heinrichs JL, Daenthanasanmak A, Iamsawat S, Schutt S, Fu J, Wu Y, Fairlie DP, Atkinson C, Ogretmen B, Tomlinson S, Yu X-Z. Complement C3a and C5a receptors promote GVHD by suppressing mitophagy in recipient dendritic cells.

JCI Insight 2018, 3(24), pii: 121697. 

 

Ramnath D, Irvine KM, Lukowski SW, Horsfall LU, Loh Z, Clouston AD, Patel P, Iyer A, Stow JL, Schroder K, Fairlie DP, Powell JE, Powell EE, Sweet MJ. Hepatic expression profiling by RNA sequencing identifies genes associated with steatosis-independent and steatosis-driven advanced fibrosis.

JCI Insight 2018, 3(14), pii: 120274. 

 

Jiang Y, Yau MK, Lim J, Wu KC, Xu W, Suen JY, Fairlie DP.  A potent antagonist of protease-activated receptor 2 that inhibits multiple signalling functions in human cancer cells. 

J Pharmacol Exp Ther 2018, 364, 246-257. 

 

Wu C, Hoang HN, Liu L, Fairlie DP. Glucuronic acid as a helix-inducing linker in short peptides.

Chem Commun 2018, 54, 2162 – 2165. 

 

Perry SR, Hill TA, de Araujo AD, Hoang HN, Fairlie DP. Contiguous hydrophobic and charged surface patches in short helix-constrained peptides drive cell permeability. 

Org Biomol Chem 2018, 16, 367-371. 

 

Shakespear MR, Iyer A, Cheng C, Das Gupta K, Singhal A, Fairlie DP, Sweet MJ. 

Lysine deacetylases and regulated glycolysis in macrophages.

Trends in Imunology 2018, 39, 473-488. 

 

D'Souza C, Pediongco T, Wang H, Scheerlinck JY, Kostenko L, Esterbauer R, Stent AW, Eckle SBG, Meehan BS, Strugnell RA, Liu L, Mak JYW, Lovrecz G, Lu L, Fairlie DP, Rossjohn J, McCluskey J, Every AL, Chen Z, Corbett AJ. Mucosal-associated invariant T cells augment immunopathology and gastritis Helicobacter pylori infection. 

J Immunol 2018, 200, 1901-1916. 

 

Gherardin NA, Loh L, Admojo L, Davenport AJ, Richardson K, Rogers A, Darcy PK, Jenkins MR, Trapani JA, Prince HM, Harrison SJ, Quach H, Fairlie DP, Kedzierska K, McCluskey J, Uldrich AP, Neeson PJ, Ritchie DS, Godfrey DI. Enumeration, functional responses and cytotoxic capacity of MAIT cells in newly diagnosed and relapsed myeloma.

Science Reports 2018, 8, 4159.

 

Gherardin NA, Souter MNT, Koay H-F, Mangas KM, Seemann T, Stinear TP, Eckle SBG, Berzins SP, d'Udekem Y, Konstantinov IE, Fairlie DP, Ritchie DS, Neeson PJ, Pellicci DG, Uldrich AP, McCluskey J, Godfrey DI. Human blood MAIT cell subsets defined using MR1 tetramers.

Immunology & Cell Biology 2018, 96, 507-525. ISI Highly Cited

 

Kjer-Nielsen L, Corbett AJ, Chen Z, Liu L, Mak J, Rossjohn J, Fairlie DP, McCluskey J, SBG Eckle. An overview on identification of MAIT cell antigens.

Immunology & Cell Biology 2018, 96, 573-587. 

 

Kim SH, Redvers RP, Chi LH, Ling X, Lucke AJ, Reid RC, Fairlie DP, Baptista Moreno Martin AC, Anderson RL, Denoyer D, Pouliot N.  Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis.

Dis Model Mech 2018, 11(7), pii: DMM034850.

 

 

2017

 

Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a. Lohman RJ, Hamidon JK, Reid RC,

Rowley JA, Yau MK, Halili MA, Nielsen DS, Lim J, Wu KC, Loh Z, Do A, Suen JY, Iyer A, Fairlie DP. 

Nature Communications20178, 351.

 

Stabilising short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells. Mak JYW, Xu W, Reid RC,

Corbett AJ, Meehan B, Wang H, Chen Z, Rossjohn J, McCluskey J, Liu L, Fairlie DP. 

Nature Communications20178, 14599.

 

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells. Drugs and drug-like molecules can modulate

the function of mucosal-associated invariant T cells. Keller AN, Eckle SB, Xu W, Liu L, Hughes VA, Mak JY, Meehan BS, Pediongco T,

Birkinshaw RW, Chen Z, Wang H, D'Souza C, Kjer-Nielsen L, Gherardin NA, Godfrey DI, Kostenko L, Corbett AJ, Purcell AW, Fairlie DP*,

McCluskey J*, Rossjohn J*.   

Nature Immunology201718, 402-411.

 

Orally Absorbed Cyclic Peptides. Nielsen DS, Shepherd NE, Xu W, Lucke AJ, Stoermer MJ, Fairlie DP. 

Chemical Reviews2017117, 8094-8128.

 

Protease activated receptor 2 controls myelin development, resiliency and repair.Yoon H, Radulovic M, Walters G, Paulsen AR, Drucker K,

Starski P, Wu J, Fairlie DP, Scarisbrick IA.  

GLIA. 2017, 65, 2070-2086.

 

Europium-Labeled Synthetic C3a Protein as a Novel Fluorescent Probe for Human Complement C3a ReceptorDantas de Araujo A, Wu C, Wu KC,

Reid RC, Durek T, Lim J, Fairlie DP.  

Bioconjug Chem201728, 1669-1676.

 

The Ribosomal Protein S19 Suppresses Antitumor Immune Responses via the Complement C5a Receptor 1.Markiewski MM, Vadrevu SK, Sharma SK,

Chintala NK, Ghouse S, Cho JH, Fairlie DP, Paterson Y, Astrinidis A, Karbowniczek M.  

J Immunol2017198, 2989-2999.

 

Biased signaling by agonists of protease activated receptor 2.Jiang Y, Yau MK, Kok WM, Lim J, Wu KC, Liu L, Hill TA, Suen JY, Fairlie DP.  

ACS Chem Biol201712, 1217-1226.

 

Mapping transmembrane residues of proteinase activated receptor 2 (PAR2) that influence ligand-modulated calcium signaling.Suen JY, Adams MN,

Lim J, Madala PK, Xu W, Cotterell AJ, He Y, Yau MK, Hooper JD, Fairlie DP.  

Pharmacol Research2017117, 328-342.

 

Total Synthesis of Mycobacterium tuberculosis Dideoxymycobactin-838 and Stereoisomers: Diverse CD1a-Restricted T Cells Display a Common

Hierarchy of Lipopeptide Recognition. Cheng JM, Liu L, Pellicci DG, Reddiex SJ, Cotton RN, Cheng TY, Young DC, Van Rhijn I, Moody DB, Rossjohn J,

Fairlie DP*, Godfrey DI*, Williams SJ*.  

Chemistry201723, 1694-1701.

 

Stereoelectronic effects on dienophile separation influence the Diels-Alder synthesis of molecular clefts.Stoermer MJ, Wickramasinghe WA,

Byriel KA, Hockless DCR, Skelton BW, Sobolev AN, White AH, Mak JYW, Fairlie DP.   

Eur J Org Chem2017 , 6793-6796.

 

Downsizing Proto-oncogene cFos to short helix-constrained peptides that bind Jun.Baxter D, Perry SR, Hill TA, Kok WM, Zaccai NR, Brady RI,

Fairlie DP,* Mason JM*.  

ACS Chem Biol201712, 2051-2061.

 

Tolyporphin Macrocycles from the Cyanobacterium Tolypothrix nodosa Selectively Bind Copper and Silver and Reverse Multidrug Resistance.

Prinsep MR, Appleton TG, Hanson GR, Lane I, Smith CD, Puddick J, Fairlie DP.     

Inorg Chem201756, 5577-5585.

 

Histone deacetylases (HDAC) in physiological and pathological bone remodelling.Cantley MD, Zannettino AC, Bartold PM, Fairlie DP, Haynes DR.  

Bone201795, 162-174.

 

Alpha Helix Nucleation by a Simple Cyclic TetrapeptideHoang HN, Wu C, Beyer RL, Hill TA, Fairlie DP.  

Aust J Chem201770, 213-219.

 

Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory

signals.Chen Z, Wang H, D'Souza C, Sun S, Kostenko L, Eckle SB, Meehan BS, Jackson DC, Strugnell RA, Cao H, Wang N, Fairlie DP, Liu L, Godfrey DI,

Rossjohn J, McCluskey J, Corbett AJ.   

Mucosal Immunol201710, 58-68.

 

Electrophilic helical peptides that bond covalently, irreversibly and selectively in a protein-protein interaction site.Dantas de Araujo A, Lim J, Good AC,

Skerlj RT, Fairlie DP.  

ACS Med Chem Lett20178, 22-26.

 

An HDAC6 inhibitor confers protection and selectively inhibits B-cell infiltration in DSS-induced colitis in mice.Do A, Reid RC, Lohman RJ, Sweet MJ,

Fairlie DP*, Iyer A*.  

J Pharmacol Exp Ther2017360, 140-151.

 

Helix-constraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta arrestin 2 signalling.Plisson F, Hill TA, Mitchell JM,

Hoang HN, de Araujo AD, Xu W, Cotterell A, Edmonds DJ, Stanton RV, Derksen DR, Loria PM, Griffith DA, Price DA, Liras S, Fairlie DP.  

Eur J Med Chem2017127, 703-714.


2016

 

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage. Koay H-F, Gherardin NA, Enders A, Loh L, Mackay LK,

Almeida CF, Russ BE, Nold-Petry CA, Nold MF, Bedoui S, Chen Z, Corbett AJ, Eckle SBG, Meehan B, d'Udekem Y, Konstantinov IE, Lappas M, Liu L, Goodnow CG,

Fairlie DP, Rossjohn J, Chong MM, Kedzierska K, Berzins SP, Belz GT, McCluskey J, Uldrich AP, Godfrey DI, and Pellicci DG. 

Nature Immunology201617, 1300-1311.

 

PAR2 modulators derived from GB88. Yau MK, Liu L, Suen JY, Lim J, Lohman RJ, Cotterell AJ, Barry GD, Mak JYC, Vesey DA, Reid RC, Fairlie DP.  

ACS Med Chem Lett 20167, 1179-1184.

 

Product release is rate-limiting for catalytic processing by Dengue virus protease.Shannon, AE, Pedroso MM, Chappell KJ, Watterson D, Liebscher S, Kok WM,

Fairlie DP, Schenk G, Young PR. 

Science Reports20166, 24575.

 

Downsizing the BAD BH3 peptide to small constrained α-helices with improved ligand efficiency. Shepherd NE, Harrison RS, Ruiz-Gomez G, Abbenante G,

Mason JM, Fairlie DP.  

Org Biomol Chem201614, 10939-10945.

 

Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activation. Loh L, Wang Z, Sant S, Koutsakos M,

Jegaskanda S, Corbett AJ, Liu L, Fairlie DP, Crowe J, Rossjohn J, Xu J, Doherty PC, McCluskey J, Kedzierska K. 

PNAS2016113, 10133-10138.

 

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2.